The Terrapins (15-1, 3-0) scored the first six points and never trailed in their third straight lopsided victory since an 87-81 loss to top-ranked UConn.
Freshman Destiny Slocum chipped in with 16 points and Kristen Confroy added 12 for Maryland, the two-time defending conference champions. The Terps and No. 11 Ohio State are the only undefeated teams in Big Ten play.
Nia Coffey scored 22 for Northwestern (13-4, 2-2) and Christen Inman had 17. Coffey, the team's leading scorer, failed to make a basket in the first half and fouled out with 8:15 left.
With the 6-foot-3 Jones leading the way, the Terrapins finished with a 47-30 rebounding advantage. It was Jones' sixth straight double-double and 10th this season.
Slocum and Walker-Kimbrough each scored 11, and the Terrapins made a half-dozen 3-pointers in taking a 45-22 lead at halftime.
Northwestern committed turnovers on its first three possessions and trailed 23-10 after missing 14 of 18 shots in the first quarter.
After the Wildcats opened the second period with a basket, Maryland resumed the onslaught. Slocum and Confroy each made a pair of 3-pointers, and Walker-Kimbrough also connected from beyond the arc during an 18-4 run that made it 41-16.
Northwestern went 8 for 30 from the floor before halftime. The Wildcats came into the game averaging 73.8 points and were coming off an 87-point performance in a loss to Ohio State.
The Terps are 6-0 vs. the Wildcats and are 2-0 vs. Northwestern at XFINITY Center. Brenda Frese is 7-0 vs. Northwestern.
The Terrapins will welcome Penn State (11-4, 1-2) to the XFINITY Center Wednesday for a 6:30 p.m. matchup. For tickets, click here or call the Terrapin Ticket Office online at 1-800-IM-A-TERP.
The matchup can also be heard online through the Maryland Sports Network on 1300 AM in Baltimore, 570 AM in Washington and the TuneIn app.