Maryland (23-6, 11-5 B1G) trailed by 24-8, but went on a 15-3 run to close the gap to a five-point deficit at halftime.
Jake Layman his torrid shooting pace, by connecting on 7-of-8 shots for 15 points. The 6-8 senior has made 12 of his last 14 field goal attempts over the past two games.
Purdue (22-7, 10-6 B1G) had five players in double figures, including a team-high 19 points by center A.J. Hammons. Hammons went 7-of-10 from the floor, including a perfect 2-for-2 from beyond the arc.
The Boilermakers maintained their lead by outrebounding Maryland, 41-22. The advantage led to 24 second-chance points as Purdue never trailed in game.
Dakota Mathias had 17 of Purdue’s 30 bench points. Jared Nickens had 10 points – including three treys - off the bench for Maryland.
Purdue shot 51.7 percent from the field to split the season series.
Maryland returns to action on Thursday when it welcomes Illinois on Senior Night at XFINITY Center. Game time is slated for 7 p.m.